• Aging and Sex
  • For men
    • Multi Vitamin for Him CPA
    • Practical Tips to Maintain Sexual Virility
    • ProSolution Plus is a Natural Remedy For Premature Ejaculation
  • for women
    • Breast Actives CPA
    • Four Ways To Look Young
    • Ten Ways to Look Like a Model Bride
  • Home Based Business
    • AWESOME EASY CASH MONEY TO YOU TODAY!
    • Craft Idea for a Group: Make a Mural
    • DIGISOFT PAYLINE How to Make Instant Money Now DIGISOFT PAYLINE
    • Getting Your Family Involved In Your Home Business
    • Home Based Real Estate Investing
    • Home Based Real Estate Investing
    • How To Become A Work At Home Mom
    • How to Get Free Rent
    • Make Extra Cash & Work From Home!
    • Strategies for Success in the Exciting and Lucrative Home-Based Business of Jewelry & Gemstones
    • THE INTERNATIONAL PROJECT OF THE 21st CENTURY
    • WIN FREE DOGECOINS EVERY HOUR!
  • How you can Regain your Youthful Appearance without Expensive Treatments or Surgery!
  • Intelligent nutritional supplements
    • Antioxidants Nutrients Have Powerful Anti-Cancer Activity!
    • AsthmaMist CPA
    • What Are Phytoceramides?
    • Cleanse the Body, Curb Unhealthy Cravings, and Lose Weight with ProShape Rx
  • interesting idea, hobby
    • Christmas Craft: Bead and Pipe Cleaner Ornaments
    • Wedding Crafts Ideas for Saving Money
  • Natural products for weight loss
    • Natural Weight Loss Products
  • Privacy Policy
  • Terms And Conditions

Health and Beauty

The site is about the beauty and health of men, women, children

  • Home

Enter your email address:

Spam Blocked

18,994 spam blocked by Akismet

Combined Biomarkers Help Detect Pancreatic Cancer Early

  • Health

Pancreatic cancer can now be detected early and can be better treated with newly identified biomarker panel, reveals a new research from the Perelman School of Medicine at University of Pennsylvania.

Currently over 53,000 people in the United States are diagnosed with pancreatic cancer the fourth leading cause of cancer death every year. The blood biomarkers, detailed today in Science Translational Medicine, correctly detected pancreatic cancer in blood samples from patients at different stages of their disease.

‘Combined blood markers such as plasma thrombospondin-2 (THBS2) and CA19-9, detect pancreatic cancer in human cancer cells early.’

The majority of pancreatic cancer patients are not diagnosed until an advanced stage, beyond the point at which their tumors can be surgically removed.

A team led by Ken Zaret, PhD, director of the Penn Institute for Regenerative Medicine and the Joseph Leidy Professor of Cell and Developmental Biology, and Gloria Petersen, PhD, from the Mayo Clinic, identified a pair of biomarkers that physicians could soon use to discover the disease earlier.

“Starting with our cell model that mimics human pancreatic cancer progression, we identified released proteins, then tested and validated a subset of these proteins as potential plasma biomarkers of this cancer,” Zaret said.

The authors anticipate that health care providers will use the early-detection biomarkers to test for their presence and levels in blood from pancreatic cancer patients and blood drawn from individuals with a high risk of developing pancreatic cancer, including those who have a first-degree relative with pancreatic cancer, are genetically predisposed to the disease, or who had a sudden onset of diabetes after the age of 50.

“Early detection of cancer has had a critical influence on lessening the impact of many types of cancer, including breast, colon, and cervical cancer. A long standing concern has been that patients with pancreatic cancer are often not diagnosed until it is too late for the best chance at effective treatment,” said Robert Vonderheide, MD, DPhil, director of the Abramson Cancer Center (ACC) at the University of Pennsylvania.

“Having a biomarker test for this disease could dramatically alter the outlook for these patients.”

The biomarker panel, enabled by discovery work of first author Jungsun Kim, PhD, a postdoctoral fellow in Zaret’s lab, builds on a first-of-its-kind human-cell model of pancreatic cancer progression the lab described in 2013. They used stem-cell technology to create a cell line from a patient with advanced pancreatic ductal adenocarcinoma.

Genetically reprogramming late-stage human cancer cells to a stem-cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early-stage disease along the way.

The best candidate biomarker, plasma thrombospondin-2 (THBS2), was screened against 746 cancer and control plasma samples using an inexpensive, commercially available protein-detection assay. The team found that blood levels of THBS2, combined with levels of a known later-stage biomarker called CA19-9, was reliable at detecting the presence of pancreatic cancer in patients.

The team refined the assay with independent investigations of plasma samples from patients with different stages of cancer, from individuals with benign pancreatic disease, and from healthy controls, all obtained from Petersen, who directs the biospecimen resource program for pancreas research at the Mayo Clinic.

“Positive results for THBS2 or CA19-9 concentrations in the blood consistently and correctly identified all stages of the cancer,” Zaret said. “Notably, THBS2 concentrations combined with CA19-9 identified early stages better than any other known method.”

The combination panel also improved the ability to distinguish cases of cancer from pancreatitis. The panel will next be validated in a set of samples from pancreatic cancer patients who provided a research blood sample prior to their diagnosis.

Source: Eurekalert

Let’s block ads! (Why?)

July 16, 2017 admin

Post navigation

How to Get Rid of Stress in 10 Minutes Flat → ← Athlete's Foot

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

  • Genital Warts Natural and Alternative Treatment Remedies 1,696 views
  • ‘Love Hormone’ Oxytocin May Enhance Feelings Of Spirituality 942 views
  • WIN FREE DOGECOINS EVERY HOUR! 889 views
  • Ginseng: Root of Immortality 855 views
  • Get Rid of Cellulite, Once and For All! 708 views
  • THE INTERNATIONAL PROJECT OF THE 21st CENTURY 696 views
  • Breast Actives CPA 693 views
  • for women 685 views

Popular articles

  • Genital Warts Natural and Alternative Treatment Remedies 1,696 views | under alternative medetsina
  • ‘Love Hormone’ Oxytocin May Enhance Feelings Of Spirituality 942 views | under alternative medetsina
  • WIN FREE DOGECOINS EVERY HOUR! 889 views
  • Ginseng: Root of Immortality 855 views | under alternative medetsina
  • Get Rid of Cellulite, Once and For All! 708 views | under Body Health
  • THE INTERNATIONAL PROJECT OF THE 21st CENTURY 696 views
  • Breast Actives CPA 693 views
  • for women 685 views
Buy Brand Drugs

Archives

Powered by WordPress | theme SG Double